Beilstein J. Org. Chem.2013,9, 1194–1201, doi:10.3762/bjoc.9.135
to affect the selective oxidation of ring-fused aminals to dihydroquinazolines and quinazolinones, respectively. These methods enable the facile preparation of a number of quinazolinealkaloid natural products and their analogues.
Keywords: aminal; copper; oxygen; tert-butylhydroperoxide
; quinazolinealkaloid; Introduction
Quinazoline alkaloids are a class of naturally occurring compounds with a range of medicinal properties and have been indicated for use as bronchodilators, vasodilators, anti-inflammatory agents and acetylcholinesterase inhibitors [1][2][3][4][5]. Many of the plants these
preparation of novel materials for biological studies.
Examples of naturally occurring quinazoline alkaloids.
Different approaches to the synthesis of quinazolinealkaloid structures.
Oxidation of other aminal systems.
Optimization of conditions for deoxyvasicine (2) formation.a
Scope of the copper-catalyzed
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Graphical Abstract
Figure 1:
Examples of naturally occurring quinazoline alkaloids.